Not provided by employer
Position:
Senior scientist/principal scientist, pbpk modeling (multiple locations)
Function:
Small molecule discovery
Location:
Remote
Position summary:
Loxo oncology at lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patientsLoxo oncology at lilly was created in december 2019, combining the lilly research laboratories oncology organization and loxo oncology, which was acquired by lilly in early 2019The unit has team members in louisville, co, indianapolis, in, new york city, ny, south san francisco, ca, san diego, ca, stamford, ct, and madrid, spain.
Loxo oncology is seeking a highly motivated pbpk modeler join our dmpk teamThe ideal candidate will have strong background and expertise in pharmacokinetics (pk) and adme concepts as well as hands-on experience with pbpk modelingThis position will contribute to the conduct of mechanistic pbpk modeling, human pk predictions, pbbm, and ddi projections to support discovery and development projects, enabling compound progression from discovery to early stages of clinical development.
Roles and responsibilities for the position
Work closely with discovery project teams to influence programs at tpp design, lead optimiztion, candidate seeking and nomination.
Utilize pbpk and translational modeling tools to enable human pk projections throughout the life of a program
Evaluate and guide novel in vitro tools and methodology to improve prediction of human pk
Proactively lead cutting edge effort to build and refine pbpk models for novel drug modalities (covalent inhibitors, protacs, ppi’s etc.).
Liaise with dmpk, discovery biology/pharmacology and clinical scientists to generate data and knowledge supporting the build-up of translational, mechanistic models
Ensure communication is effective and clear for internally and externally on topics related to pbpk, translational modeling and simulation, human pk and ddi prediction
Keep abreast of emerging literature and science in modeling and in vitro approaches
Required qualifications and preferred background
Bachelors, masters, or phd with 0-4 (phd), 8-10 (ms), or 10-12 (bs) years of experience in pharmaceutical or relate
Hands-on project experience in pbpk modeling and simulation through internship, industry research collaboration, or direct industry experience strongly preferred.
Successful track record of applying pbpk into projects
Strong understanding of adme, pk and ddi concepts as well as significant theoretical and practical understanding of own scientific discipline
Focus on and passion for data analysis, solving technical problems and applying new technologies to further scientific goals.
Hands-on experience in the use of commercial pbpk modeling software (simcyp or gastroplus is preferred)
Loxo oncology, inc(loxo) currently anticipates that the base salary for the senior scientist position level could range from between $89,750 to $131,672 and that the base salary for the principal scientist position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experienceThis position also will be eligible for a company bonus (depending, in part, on company and individual performance)In addition, loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain itemsThe compensation described above is subject to change and could be higher or lower than the range described aboveFurther, loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Available locations for this role
Us based-remote
Boulder, colorado
San diego, ca
To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorilyThe requirements listed above are representative of the knowledge, skill, and/or ability requiredReasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo oncology, incIs an eeo/affirmative action employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected statusAs a condition of employment with eli lilly and company and its subsidiaries in the united states and puerto rico, you must be fully covid-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law)Loxo oncology, inc(“loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobsIf you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at loxo, please email loxoaccommodation@loxooncology.com for further assistancePlease note, this email address is intended for use to request an accommodation as a part of the application processAny other correspondence will not receive a response.
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